SMAC Mimetics Affect Human T-Cell Proliferation and Cytokine Production
Susan Murray, Faculty Mentor
- Abstract
- SMAC mimetics, chemotherapy drugs which imitate the natural SMAC molecules produced by the mitochondria, are of high interest to cancer research due to their ability to induce apoptosis in cancer cells. They have also been hypothesized to act on cells of the immune system, augmenting their ability to generate an anti-cancer response. We have found that SMAC mimetics tend to decrease proliferation in human T cells while simultaneously increasing their expression of a common activation marker, CD25. The production of cytokines in T cells seems to be impacted by exposure to SMAC mimetics, but has not shown a clear trend. If our work identifies a connection between the use of SMAC mimetics and immune function, it would demonstrate a potential to fend off cancer from both an immunotherapy and chemotherapy approach.
- Presented by
- Ashley Burton and Brittany Ligman
- Program
- CAS Summer Undergraduate Research Experience
- Hashtags
- #CAS #10:20 #STEM



























